Section: USMLE

29) A 24-year-old woman with a history of allergic rhinitis is involved in an automobile accident and sustains a splenic laceration. She undergoes abdominal surgery and is then transfused with four units of blood of the appropriate ABO and Rh type. As the transfusion progresses, she becomes rapidly hypotensive and develops airway edema, consistent with anaphylaxis. Which of the following pre-existing conditions best accounts for these symptoms?

1. AIDS
2. C1 esterase inhibitor deficiency
3. DiGeorge syndrome
4. Selective IgA deficiency
5. Wiskott-Aldrich syndrome